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Organic compounds that contain an aromatic ring with one or more hydrogen atoms replaced by a halogen atom; also known as haloarene or halogenoarene. Halogen atoms include bromine, chlorine, fluorine, iodine.
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Iodo-PEG3-N3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs employ the intracellular ubiquitin-proteasome system to specifically degrade target proteins.
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MyoMed 205 is an inhibitor that targets the activity of MuRF1. It prevents early diaphragmatic systolic dysfunction and atrophy caused by unilateral diaphragmatic nerve denervation. This compound reduces ubiquitination and subsequent proteasomal degradation of muscle proteins by inhibiting MuRF1 activity. It also increases the levels of a protein that phosphorylates Akt (ser473), a crucial signaling molecule for muscle growth and maintenance. MyoMed 205 can be used for studying and treating diaphragmatic dysfunction and atrophy (DIDD).
Targets the activity of MuRF1.
Prevents early diaphragmatic systolic dysfunction and atrophy.
Reduces ubiquitination and proteasomal degradation of muscle proteins.
Increases levels of protein that phosphorylates Akt (ser473).
Useful for studying and treating diaphragmatic dysfunction and atrophy (DIDD).
For research use only.
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5-Iodo-A-85380 dihydrochloride is a high-affinity, small-molecule ligand and agonist for neuronal nicotinic acetylcholine receptors, with strong selectivity for the α4β2 subtype. It is supplied as the dihydrochloride salt for research use only and has a reported binding Kd of ≈12-14 pM.
High affinity for α4β2 nicotinic acetylcholine receptors (Kd ≈12-14 pM).
Selective agonist activity at α4β2 and α6β2 receptor subtypes.
Supplied as the dihydrochloride salt for improved stability and handling.
High purity suitable for research use (≈99.0%).
Available in small-scale pack sizes for laboratory studies.
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DEC-205/CD205 protein acts as an endocytic receptor directing antigens to an antigen-processing compartment It also reduces B lymphocyte proliferation DEC-205/CD205 Protein Mouse (HEK293 His) is the recombinant mouse-derived DEC-205/CD205 protein expressed by HEK293 with C-His labeled tag
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7-iodo-2',3'-dideoxy-7-deaza-guanosine is an iodinated dideoxynucleoside used as a chain-terminating nucleotide in DNA synthesis and sequencing reactions. It is supplied as a solid and is also available as a 10 mM solution in DMSO; analytical purity is listed at 99.17%.
used as a chain terminator in DNA synthesis and sequencing
available as a solid and as a 10 mM solution in DMSO
high analytical purity suitable for research applications
molecular weight 376.15 g/mol and formula C11H13IN4O3
CAS number 114748-67-3
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